Application notes

Application Note #1:

Using large-volume superconvective PCR to overcome PCR inhibition

Large-volume superconvective real-time PCR*, using the QuanTyper?48 instrument, overcomes inhibitor induced amplification failure in bovine feces samples. This could have positive implications in situations where diagnosis of a disease is based on real-time PCR analysis of DNA originating from bovine feces, e.g. Johne’s disease.

Application Note #2:

Using superconvective DNA amplification to speed up Sanger sequence analysis of forensic mitochondrial DNA samples

Quick and simple preparation/amplification of DNA samples, combined with fast DNA sequencing, is of great interest to the forensic genetics community. In this study the QuanTyper?48 instrument has been used to speed up the amplification steps involved in Sanger DNA sequencing.

Application Note #3

Discrimination of base-pair neutral single nucleotide polymorphism (SNP) by highresolution melting on QuanTyper?48

High-resolution melting (HRM) analysis has recently emerged as a simple, rapid and cost-effective method for mutation screening and genotyping of single nucleotide polymorphisms. In this study, we show that the most subtle and hard to detect genetic variation, an A/T conversion, is possible to genotype by HRM on QuanTyper-48.
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Tel: +46 18 12 07 01
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